Evaluation of the pharmacological activity of hybrid organotin compounds in a B16 melanoma model in the classical and metronomic administration modes

Introduction: In modern medical chemistry, much attention is paid to the search for new antimetastatic agents based on metal compounds. Organotin compounds promise be good candidates as treatment of malignant neoplasms. order reduce a possible nonspecific toxic effect tin and expand intended therapeutic use, paper presents hybrid (IV) complexes with Sn-S bond containing fragment 2,6-di-tert-butylphenol. The aim study was evaluate antitumor effects bis (3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethylolol (Me3) triphenylolol (Me5) in model transplanted melanoma tumor B16 mice classical metronomic administration mode.
 Materials methods: efficacy organotin studied spontaneous metastasis C57Bl/6 (female) using following indicators: average life expectan­cy, inhibition growth by weight, mass, index.
 Results discussion: most pronounced (54% 36%) achieved five-fold in­traperitoneal injection Me3 Me5 at total doses 375 mg/kg 250 mg/kg. comparable results were obtained modes With an increase injected dose, there activating process generalized metastasis.
 Conclusion: Bis demonstrate both activity multidirectional primary focus lungs, depending dose.